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In general, A plaques in the striatum are linked to lower levels of motivation and dopamine transporter (DAT) expression ( Anxiety-like behavior and related pathology in AD mouse models Anxiety-like behaviors can be assessed using various behavioral tests, including the open field test (OFT), elevated plus maze (EPM), light-dark box, social interaction, and novelty-suppressed feeding

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Identification of the metabolic differences between microbial pathogens and their hosts, as well as the design of species-specific antimicrobial agents targeting the differential metabolic pathways, therefore represent the most promising fields of research and are strongly supported by recent developments in biological methodology and system biology that allow a better understanding of pathogenic mechanisms at various levels [8, 22, 59]